ruin

[1]	destroy , destroy , devastate , demolish , annihilate , dissolve , wipe out , undo , overthrow , lay waste , raze , shatter , wreck , crush , flatten , wreak havoc (up)on , reduce to nothing/naught , pulverize , smash , bring to ruin
[2]	spoil , disfigure , damage , botch , mess up , make a mess of , mar , uglify
[3]	spoil , bankrupt , break , destroy , wreck , smash , nullify , damage , harm , hurt , impair , poison , (Slang) louse up , screw up , put the kibosh on , (US) bollix up , (Colloq) (Slang) (Mainly Brit) make a balls-up of
[4]	bankrupt , pauperize , impoverish , reduce to penury/poverty/destitution/indigence
[5]	violate , deflower , deflower , ravish , seduce , lead astray , dishonour , defile , corrupt , debase , defile

[1]	ruination , downfall , destruction , devastation , havoc , breakdown , breakup , debacle , collapse , fall , disintegration , ruination , dissolution , wiping out , failure , decay , undoing , end , conquest , defeat , overthrow , bankruptcy , liquidation , failure
[2]	degradation , dishonour , debasement , defilement , corruption , vitiation , seduction , degrading , dishonouring , debasing , defiling , corrupting , vitiating , seducing , deflowering , defloration
[3]	nemesis , dilapidation , curse , end , bane , curse
[4]	gin , ruination , mother's ruin , blue ruin , (Slang) rot-gut
[5]	hag , downfall , ruination , witch , crone , beldam , dotard , (old) fogy/fogey , fossil , fuddy-duddy , antique , (Brit) OAP (old-age pensioner) , (Mainly US) retiree , (Colloq) (old) geezer , wreck , (Slang) dodo
[6]	ruins , laying waste , ruining , debris , wreckage , ruination , wrecking , fragments , rubble , remains