gist

[1]	effect , essence , core , essence , heart , burden , core , substance , point , theme , quintessence , pith , meat , marrow , focus , nub , significance , (main/basic) idea , direction , drift
[2]	kernel , substance , core , center , centre , essence , heart , heart and soul , inwardness , marrow , meat , nub , pith , sum , nitty-gritty